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Human Papilloma Virus Vaccines: Implications for use in developing world

Atul Kumar AGARWAL
3.915 877


Cervical cancer may be substantially prevented by human papillomavirus (HPV) vaccination. The two most common oncogenic HPV types causing 70% of all cervical cancers are represented in the vaccines by synthetic virus-like particles to the L1 protein of HPV 16 and 18. The virus-like particles and adjuvant systems promote long-term antibody response. Invasive cervical cancer (ICC) is the second most common cancer among women worldwide. Approximately 85% of the disease burden is seen in women in developing nations. India with its highest share of global burden of cervical cancer has to implement a population based cervical cancer control program to reduce the number of deaths. Development of effective vaccines against human papillomavirus, the necessary cause of cervical cancer, has introduced a fresh lease of life to the cervical cancer control strategies. Vaccination programs targeted to a large age range of women will achieve cervical cancer reductions several decades from now.


human papillomavirus, human papillomavirus vaccination

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